£400.00
Description
SenTraGor™ – A unique reagent for detection of cellular senescence:
Conclusive, reliable, antibody-enhanced detection of senescent cells.
SenTraGor™ is a biotin linked Sudan Black B (SBB) analogue tracing lipofuscin in senescent cells.
Cellular senescence is a biological process involved in normal embryonic and adult life and increases with age. It also occurs in the frame of various diseases and after therapeutic interventions. Detection and measurement of senescent cells is critical and highly desired in research and clinical practice. Senescent cells are found in a wide spectrum of age related disorders, including cancer.
SenTraGor™, an SBB analogue conjugated with biotin, reacts with lipofuscin granules that have been shown to accumulate during the senescence process.
Applications:
SenTraGor™ is recommended for the recognition of senescent cells.
It binds to cytoplasmic lipofuscin, a hallmark of senescent cells.
It can be applied on cells from aspiration or cell cultures as well as on tissue sections from frozen or formalin-fixed paraffin embedded (FFPE) samples.
It can be used for immunohistochemistry (IHC), immunocytochemistry (ICC), immunofluorescence (IF) and flow cytometry analysis (FACS).
